Many people might be surprised to learn that while vitamins are essential for good health, it’s minerals that need more attention since they are harder to absorb and assimilate. Calcium is one of the macro-minerals, or the essential minerals, in our diet. The U.S. RDA’S have steadily increased over the years starting at 600 milligrams a day, and now research shows that we may be upping the recommended daily allowance to 1500 milligrams a day. In this segment of DL Radio, Jordan Rubin, founder of Garden of Life, details how to choose the right calcium supplement and protect against mineral deficiencies. Save $5 on your next Garden of Life purchase. Click here!

Air-O-Swiss 7135 Microbial Ultrasonic Humidifier
Air-O-Swiss 7135 Microbial Ultrasonic Humidifier Brief Description This efficient air humidification technology uses high-frequency vibration to generate a micro-fine mist. A fan blows the mist into the room where it immediately evaporates. The 7135 Ultrasonic humidifier requires little power, has a built-in hygrostat and an output regulator button. A replaceable demineralization cartridge ensures a […]

HPA-1 polymorphism of IIb 3 modulates platelet adhesion onto immobilized fibrinogen in an in-vitro flow system
Background: Platelet adhesion and subsequent thrombus formation on a subendothelial matrix at the site of vascular damage play a crucial role in the arrest of posttraumatic bleeding but also in different pathological thrombotic events, such as acute coronary syndrome and stroke. Recently published studies have clearly demonstrated that platelet integri IIb 3 is intimately involved in the occlusive thrombus formation at the site of endothelial damage. Therefore, any genetic variation in the expression of this receptor may lead to an excessive bleeding or excessive thrombus formation. In this study, we evaluated the influence of HPA-1 polymorphism of integrin IIb 3 on platelet adhesion onto immobilized fibrinogen using an in vitro system simulating blood flow. Methods: Platelets in anticoagulated whole blood [49 healthy previously genotyped blood donors) were labelled with fluorescence dye and perfused through a rectangular flow chamber (shear rates of 50 s-1, 500 s-1 and 1500 s-1). A fluorescence laser-scan microscope was used for visualisation and quantification of platelet adhesion at 15 sec, 1 and 5 minutes after start of perfusion. Results: During perfusion, the platelet adhesion linearly increased with regard to exposition time and shear rate. Perfusion of blood preincubated with Abciximab over fibrinogen-coated cover-slips showed reduced platelet adherence (absolute fluorescence: 168 35 U vs. 53000 19000 at control experiments, p < 0.05), as well as by perfusion over BSA-coated glass coverslips. Platelet with HPA-1a/1a genotype exhibited initial better adhesion but they also exhibited higher detachment under arterial flow conditions compared to the HPA-1b/1b platelets. Analysis of stable adhesion rate indicate that the platelets carrying the HPA-1b/1b genotype have a higher reactivity threshold for initial interaction with fibrinogen but under the higher shear rate (in regard to time of perfusion) also realize more stable bonds with fibrinogen than platelets with the HPA-1a/1a genotype. Conclusion: Our data support the contention that genetically determined variants of platelet integrins IIb 3 could play a role in arterial thrombogenesis and thus confirm the hypothesis derived from epidemiological studies.

How to choose the right multivitamin
The U.S. diet is not what it used to be, but still not what it should be. Every major medical organization now recommends we take a multivitamin, but we’ve all heard that certain vitamins that we can’t break down or that don’t get into our system create nothing but expensive urine. In this segment of DL Radio, Jordan Rubin, founder of Garden of Life, explains how choosing the right type of multivitamin can make all the difference in your daily health & wellness. Save $5 on your next Garden of Life purchase. Click here!

This entry was posted on Monday, May 28th, 2007 at 6:18 am and is filed under Vitamins. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.