Congenital Syphilis in Valera, Venezuela
Congenital syphilis still poses a significant public health problem in many countries of the world. We studied epidemiology of syphilis and other sexually transmitted infections among pregnant women and their newborns during a 5-year period at a general hospital in Valera, western Venezuela finding a high incidence of disease among those newborns from infected mothers.

Evaluation of Immunochromatography Tests for Detection of Rotavirus and Norovirus among Vietnamese Children with Acute Gastroenteritis and the Emergence of a Novel Norovirus GII.4 Variant
A prospective study was conducted to evaluate two immunochromatography (ICG) tests for detection of group A rotavirus and norovirus GII, the commercial Dipstick ‘Eiken’ Rota kit (SA Scientific, USA) and the NV IC-1 stick (Immuno-Probe, Japan). Polymerase chain reaction (PCR) with specific primer pairs (Beg9 and VP7-1’, for group A rotavirus; COG2F and G2SKR, for norovirus GII) was used as the reference method. The results of ICG tests were compared with those of reference method. The sensitivity, specificity and agreement between ICG tests and PCR were 87.8%, 93.3% and 89.4%, respectively, for rotavirus ICG test; and 73.7%, 100% and 95.2%, respectively, for norovirus ICG test. The immunochromatography assay for norovirus used in this study could detect not only common noroviruses, but also a novel norovirus GII.4 variant, which emerged in Ho Chi Minh City in 2006. Immunochromatography tests are easy, rapid and useful assays for detection of rotavirus and norovirus among pediatric patients with acute gastroenteritis in Vietnam.

Evidence behind the WHO guidelines: Hospital Care for Children: What are appropriate methods of urine collection in UTI?

Understanding health insurance: A Guide to Billing and Reimbursement
Understanding health insurance: A Guide to Billing and Reimbursement Understanding health insurance: A Guide to Billing and Reimbursement, 8th Edition is a comprehensive source for teaching the subject of health insurance and reimbursement. The book contains chapters on introductory information on the health insurance field, managed health care, legal and regulatory issues, coding systems, […]

A 5-year PICU Experience of Disseminated Staphylococcal Disease, Part 2: Management, Critical Care Needs and Outcome
Staphylococcus aureus causes an impressive spectrum of disease in tropics and subtropics. Scanty data are available regarding disseminated staphylococcal disease (DSD) in children, especially on their critical care needs. It is important to recognize and prioritize patients who may benefit most from Pediatric Critical Care. The objective of this article is to review the, critical care needs, management and outcome of patients with DSD and to identify clinical indicators for need of critical care. The study setting is a Pediatric Intensive Care Unit of an urban tertiary care teaching hospital in a developing economy. Fifty-three patients (age, 1 month to 12 years) with DSD, admitted to PICU during June 1994 to June 1999, form the subjects for the study. DSD was defined as involvement of at least two distant organs with presence of Gram-positive cocci in clusters and/or growth of S. aureus from at least one normally sterile body fluid. Data regarding demographic and clinical picture, microbiological profile, indication for PICU admission, monitoring needs, medical and surgical management and outcome was retrieved from the case records. Critical care problems included septic shock (28/53), pericardial effusion (21/53, cardiac tamponade in six), raised intracranial pressure (5 patients) and refractory status epilepticus (1 patient). The majority developed septic shock after first few doses of parenteral antimicrobials. They required an impressive amount of fluid [100 (56) ml/kg] during initial 6 h of resuscitation, and 90% had myocardial dysfunction requiring inotropic support. Tracheal intubation was needed in 18 (34%) and ventilatory support in 17 (32%) patients. About 60% patients had metabolic abnormalities. Soft tissue disease was associated with high risk of septic shock (RR, 1.77; P < 0.05). Presence of both septic shock and need for ventilation was associated with high mortality (RR, 20.5; P < 0.001). Patients with suspected DSD need intensive cardio-respiratory monitoring during initial 48–72 h of therapy; and those who develops shock, respiratory failure, pericardial effusion and necrotizing soft tissue disease should be prioritized for PICU admission.

Children with Human Immunodeficiency Virus Infection Admitted to a Paediatric Intensive Care Unit in South Africa
Background: Early data regarding the outcome of human immunodeficiency virus (HIV)—infected children in paediatric intensive care units (PICU) suggested mortality as high as 100%. Recent studies report mortality of 38%. Survival depends on the indication for admission. Objectives: To describe the prevalence, duration of stay, and outcome of HIV-infected patients in a single PICU over a 1-year period. Additional objectives included describing the indications for admission as well as the clinical and laboratory characteristics of HIV-infected infants and children requiring PICU admission. Method: Retrospective chart review of all children with serological proof of HIV admitted to PICU at Tygerberg Children’s Hospital from 1 January to 31 December 2003. Results: Of the 465 patients admitted, 47 (10%) were HIV-infected. For HIV-infected children the median age on admission was 4 months. The median duration of stay was 6 days, significantly longer than for the non-HIV group (p = 0.0001). Fifty-seven percent had advanced clinical and immunological disease. Seventeen died in PICU and four shortly afterwards, poor PICU outcome was significantly associated with HIV status (p = 0.001). Lower total lymphocyte count (p = 0.004) and higher gamma globulin level (p = 0.04) were paradoxically the only findings significantly associated with survival. Acute respiratory failure (ARF) accounted for 76% of admissions, including Pneumocystis jiroveci in 38%. Fifty-one percent had evidence of cytomegalovirus infection. Conclusions: HIV-infected children requiring PICU can survive despite the lack of availability of antiretroviral therapy.

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